Thermo Fisher Scientific PFKP Monoclonal Antibody (OTI1F2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the γ phosphate of ATP, onto an acceptor amino acid in a substrate protein. Through this mechanism, protein kinases mediate most signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family is classified into 8 major groups based on sequence comparisons of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the RAC/Akt protein kinase family, the kinases that phosphorylate G protein-coupled receptors (ARK), and the kinases that phosphorylate ribosomal protein S6 (RSK).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.