Thermo Fisher Scientific Mash1/Ascl1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

This affinity purified antibody is directed against mouse Mash1/Ascl1.
BLAST analysis suggests cross-reactivity with mouse and rat (100% homology) and human (93% homology) based on the immunizing sequence.

Target Information

ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor required for early nervous system development.
It is expressed in the fetal brain and is essential for the development and survival of subsets of autonomic neurons.
ASCL1 interaction with MEF-2A may regulate gene expression critical for neuronal circuit formation in the CNS.
High ASCL1 expression in neuroendocrine tumors such as medullary thyroid cancer and small cell lung cancer makes it a useful marker for cancers with neuroendocrine features.
The human ASCL1 gene maps to chromosome 12 and contains a trinucleotide repeat region, making it a potential candidate for inherited disease studies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.