Thermo Fisher Scientific ZFYVE19 Polyclonal Antibody
ZFYVE19 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등에 사용 가능. 인간 및 생쥐 반응성, 고순도 친화 크로마토그래피 정제, 안정적인 액상 형태로 연구용 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZFYVE19 (Accession Q96K21), corresponding to amino acid residues E315–Q365 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851395 |
Product Specific Information
Antibody detects endogenous levels of total ZFYVE19.
Target Information
ZFYVE19 is a key regulator of the abscission step in cytokinesis and part of the cytokinesis checkpoint. It prevents premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, it retains abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until checkpoint signaling is terminated. Deactivation of AURKB leads to dephosphorylation of CHMP4C, dissociation from ZFYVE19/ANCHR and VPS4, and subsequent abscission.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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