Thermo Fisher Scientific TANK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.0 µg/mL
• Publications: N/A

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 87%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%

Target Information

TANK was initially identified as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families leads to the formation of a TRAF/TANK complex that mediates activation of the transcription factor NF-kappa-B. This activation occurs through association with the kinases IKK-iota and TBK1. These proteins can form a complex with NEMO, which regulates the activity of the Ikappa-B complex. This suggests that TBK1 and IKK-iota may help modulate functions such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.