Thermo Fisher Scientific ICAM-1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt

Target Information

ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region, and a cytoplasmic domain. It has seven potential N-linked glycosylation sites and shares sequence homology with ICAM-2 (CD102) and ICAM-3 (CD50).
ICAM-1 binds to integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for Rhinovirus. It is expressed on activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, B and T lymphocytes (low), monocytes, macrophages, dendritic cells, and neutrophils. Expression increases during inflammation, and soluble ICAM-1 is detectable in plasma, elevated in various inflammatory syndromes. It is also found in some carcinoma and melanoma cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.