Thermo Fisher Scientific SR-BI Polyclonal Antibody
Thermo Fisher Scientific의 SR-BI Polyclonal Antibody는 HDL 결합 및 콜레스테롤 대사 연구에 적합합니다. Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용 가능. 염소 유래 IgG 폴리클로날 항체로, 액상 형태이며 4°C 보관.
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Thermo Fisher Scientific SR-BI Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | 1:50 | - |
| Flow Cytometry (Flow) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Hamster |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal residues 400–509 of mouse SR-BI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Wet ice |
| RRID | AB_568737 |
Product Specific Information
Suggested positive control: mouse liver lysate or protein.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism, and their plasma concentrations are inversely correlated with the risk for atherosclerosis.
The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a distinct mechanism.
In mice, SR-BI appears to play a key role in determining plasma lipoprotein cholesterol levels and cholesterol accumulation in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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