Thermo Fisher Scientific IDH1 Polyclonal Antibody
Yeast에서 반응하는 IDH1 폴리클로날 항체로 Western blot에 적합. Goat에서 유래한 IgG 형식의 비결합 항체이며, 0.5 mg/mL 농도의 액상 형태로 제공. TBS(pH 7.3, 0.5% BSA) 버퍼에 보관되며, -20°C에서 냉동 보관 필요. 연구용 전용 제품.
- 카탈로그번호
- PA5142665
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Yeast |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-EPGSRHVGLDIKGQN (aa 281–295) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933311 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizing NAD(+) and the other NADP(+) as electron acceptors.
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent forms localized to the mitochondrial matrix, and two NADP(+)-dependent forms — one mitochondrial and one predominantly cytosolic.
The encoded protein is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes, containing the PTS-1 peroxisomal targeting signal sequence.
Its presence in peroxisomes suggests roles in NADPH regeneration for intraperoxisomal reductions (e.g., conversion of 2,4-dienoyl-CoAs to 3-enoyl-CoAs) and in peroxisomal reactions consuming 2-oxoglutarate, such as alpha-hydroxylation of phytanic acid.
The cytoplasmic enzyme plays a key role in cytoplasmic NADPH production.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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