Thermo Fisher Scientific AIFM1 Monoclonal Antibody (OTI4E6), TrueMAB
AIFM1 단백질을 인식하는 Mouse 모노클로날 항체로, Western blot 및 IHC(P) 응용에 적합합니다. 인간 및 마우스 반응성을 가지며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 -20°C에서 보관하며 재동결을 피해야 합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 134–483 of human AIFM1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis Inducing Factor (AIF) is involved in chromatin condensation and DNA fragmentation during apoptosis. AIF localizes in mitochondria and translocates to the nucleus upon induction of apoptosis, promoting the release of cytochrome c and caspase-9. It induces chromatin condensation and large-scale DNA fragmentation, key features of apoptosis. AIF is highly conserved between human and mouse and is widely expressed. Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, leading to severe mitochondrial encephalomyopathy. Alternative splicing generates multiple transcript variants, and a pseudogene is identified on chromosome 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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