Thermo Fisher Scientific PBX1 Polyclonal Antibody
Thermo Fisher Scientific의 PBX1 폴리클로날 항체는 인간 PBX1 단백질을 표적으로 하는 연구용 항체입니다. Western blot, IHC, ICC/IF에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PBX1. Recombinant protein control fragment (Product #RP-101911) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789279 |
Product Specific Information
Immunogen sequence:
YSHLSNPYPS EEAKEELAKK CGITVSQVSN WFGNKRIRYK KNIGKFQEEA NIYAAKTAVT ATNVSAHGSQ ANSPSTPNSA GSSSSFNMSN SGDLFMSVQS LNGDSYQGAQ VGANVQSQVD TLRHVISQTG GYSDGLAASQ MYSP
Target Information
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming.
A chromosomal translocation, t(1;19), involving this gene and the TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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