Thermo Fisher Scientific IFN alpha Monoclonal Antibody (2-48)

Applications

Product Specifications

Product Specific Information

Alpha interferons are involved in virus resistance in target cells. They block cell proliferation and regulate MHC class I antigen expression. The IFNα family includes over 20 genes and pseudogenes in two families (I and II), with mature lengths of 166 or 172 amino acids. IFNα is produced by lymphocytes, monocytes, macrophages, and cell lines such as Namalwa and KGI.

Bioassays for IFNα include cytopathic effect blocking assays using viruses such as VSV, SFV, and BMCV. Receptors for IFNα are expressed on most cell types. Clone 2-48 is specific for human interferon α1 and does not cross-react with human interferon α2.

Target Information

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins found in vertebrates. Interaction with its receptor activates signaling pathways involved in innate immune responses against viral infection. In humans, the IFN alpha gene is located on chromosome 9. The Type I interferon family includes 14 alpha isoforms and single beta, omega, epsilon, and kappa isoforms.

IFN alpha is primarily produced by plasmacytoid dendritic cells and plays a key role in antiviral innate immunity and modulation of adaptive immune responses. Dysregulation of IFN alpha is associated with diseases such as Hepatitis C and Hepatitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.