Thermo Fisher Scientific SESN1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SESN1 (NP_055269.1, 1 a.a. approximately 551 a.a) full-length human protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MAEGENEVRW DGLCSRDSTT RETALENIRQ TILRKTEYLR SVKETPHRPS DGLSNTESSD GLNKLLAHLL MLSKRCPFKD VREKSEFILK SIQELGIRIP RPLGQGPSRF IPEKEILQVG SEDAQMHALF ADSFAALGRL DNITLVMVFH PQYLESFLKT QHYLLQMDGP LPLHYRHYIG IMAAARHQCS YLVNLHVNDF LHVGGDPKWL NGLENAPQKL QNLGELNKVL AHRPWLITKE HIEGLLKAEE HSWSLAELVH AVVLLTHYHS LASFTFGCGI SPEIHCDGGH TFRPPSVSNY CICDITNGNH SVDEMPVNSA ENVSVSDSFF EVEALMEKMR QLQECRDEEE ASQEEMASRF EIEKRESMFV FSSDDEEVTP ARAVSRHFED TSYGYKDFSR HGMHVPTFRV QDYCWEDHGY SLVNRLYPDV GQLIDEKFHI AYNLTYNTMA MHKDVDTSML RRAIWNYIHC MFGIRYDDYD YGEINQLLDR SFKVYIKTVV CTPEKVTKRM YDSFWRQFKH SEKVHVNLLL IEARMQAELL YALRAITRYM T

Target Information

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.