Thermo Fisher Scientific SESN1 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Protein Sequence:
MAEGENEVRW DGLCSRDSTT RETALENIRQ TILRKTEYLR SVKETPHRPS DGLSNTESSD GLNKLLAHLL MLSKRCPFKD VREKSEFILK SIQELGIRIP RPLGQGPSRF IPEKEILQVG SEDAQMHALF ADSFAALGRL DNITLVMVFH PQYLESFLKT QHYLLQMDGP LPLHYRHYIG IMAAARHQCS YLVNLHVNDF LHVGGDPKWL NGLENAPQKL QNLGELNKVL AHRPWLITKE HIEGLLKAEE HSWSLAELVH AVVLLTHYHS LASFTFGCGI SPEIHCDGGH TFRPPSVSNY CICDITNGNH SVDEMPVNSA ENVSVSDSFF EVEALMEKMR QLQECRDEEE ASQEEMASRF EIEKRESMFV FSSDDEEVTP ARAVSRHFED TSYGYKDFSR HGMHVPTFRV QDYCWEDHGY SLVNRLYPDV GQLIDEKFHI AYNLTYNTMA MHKDVDTSML RRAIWNYIHC MFGIRYDDYD YGEINQLLDR SFKVYIKTVV CTPEKVTKRM YDSFWRQFKH SEKVHVNLLL IEARMQAELL YALRAITRYM T

Target Information

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, leading to inhibition of the mammalian target of rapamycin (mTOR) protein. It also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins. Expression of this gene is a potential marker for radiation exposure. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.