Thermo Fisher Scientific CADM1 Polyclonal Antibody
CADM1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, 친화 크로마토그래피 정제. 종양 억제 및 세포 부착 관련 연구에 적합.
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Thermo Fisher Scientific CADM1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CADM1 (Accession Q9BY67), corresponding to amino acid residues S105–T155 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851914 |
Product Specific Information
Antibody detects endogenous levels of total CADM1.
Target Information
CADM1 mediates homophilic cell-cell adhesion in a Ca²⁺-independent manner and heterophilic adhesion with CADM3 and PVRL3. It acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes NK cell cytotoxicity and IFN-γ secretion by CD8⁺ cells, contributing to tumor rejection. CADM1 may also mediate communication between mast cells and nerves, support synapse assembly, neuronal migration, axon growth, and spermatogenesis processes.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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