
원본
ELK Biotechnology ERK 8 (phospho Thr175/Y177) rabbit pAb
상품 한눈에 보기
ERK8 단백질의 Thr175/Y177 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 적합하며 고농도(1 mg/ml)로 제공. 세포질 및 핵 내 ERK8 단백질 검출에 유용. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다회원가입 없이 바로 구매하세요
가입하지 않아도 비회원가로 구매하실 수 있습니다.
카탈로그 번호 · 상품 설명출고판매가담기
ELK Biotechnology ES5241-100UL ERK 8 (phospho Thr175/Y177) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES5241-50UL ERK 8 (phospho Thr175/Y177) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology ERK 8 (phospho Thr175/Y177) rabbit pAb
제품명
ERK 8 (phospho Thr175/Y177) rabbit pAb
제품 개요
ERK8 단백질의 Thr175 및 Tyr177 인산화 부위를 특이적으로 인식하는 토끼 폴리클로날 항체입니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에서 사용 가능하며, 세포 내 ERK8 단백질의 위치 및 활성 상태 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MAPK15; ERK7; ERK8; Mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7; Extracellular signal-regulated kinase 8; ERK-8 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human ERK8 around phosphorylation site Thr175 and Tyr177 (AA range: 141–190) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| Gene ID (Human) | 225689 |
| Human Swiss-Prot No. | Q8TD08 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cytoplasm, cytoskeleton, cilium basal body, cell junction (tight junction), microtubule organizing center (centrosome, centriole), cytoplasmic vesicle (autophagosome), Golgi apparatus, nucleus, and spindle.
Co-localizes to cytoplasm only in presence of ESRRA (PubMed:21190936). Translocates to nucleus upon activation (PubMed:20638370). Detected at spindle during meiotic stages (By similarity).
Background
- Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
- Domain: N-terminal (1–20) region necessary for ubiquitination and proteasomal degradation.
- TXY motif: Contains Thr and Tyr residues whose phosphorylation activates MAP kinases.
- Enzyme regulation: Activated by Thr and Tyr phosphorylation; inhibited by dual specificity phosphatases (e.g., DUSP1).
- Function: Phosphorylates MBP in vitro.
- PTM: Dually phosphorylated on Thr-175 and Tyr-177; autophosphorylated in vitro; ubiquitinated for regulation and turnover (possibly by SCF E3 ligase).
- Similarity: Member of protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily; contains one protein kinase domain.
- Subunit: Interacts with CSK/c-Src, ABL1, RET, and TGFB1I1.
- Tissue specificity: Widely expressed, highest in lung and kidney.
ELK Biotechnology 상품 둘러보기
전체보기문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.
