ELK Biotechnology c-Abl (phospho Tyr245) rabbit pAb
인산화 Tyr245 부위를 인식하는 c-Abl rabbit polyclonal antibody로, 세포 내 신호전달 및 암 관련 연구에 적합. WB, IF, ELISA에 사용 가능하며, 인간·마우스·랫트 반응성. 고순도 IgG, -20°C에서 1년 보관.
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c-Abl (phospho Tyr245) rabbit pAb
제품 개요
본 항체는 인간 c-Abl 단백질의 인산화 Tyr245 부위를 인식하도록 설계된 rabbit polyclonal antibody입니다. 세포 신호전달, 암 관련 연구, 단백질 인산화 조절 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | c-Abl (phospho Tyr245) rabbit pAb |
| Alternative Names | ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunofluorescence: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human c-Abl around the phosphorylation site of Tyr245 (AA range: 196–245) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 125 kDa (200 kDa BCR-ABL complex) |
| GeneID (Human) | 25 |
| Human Swiss-Prot No | P00519 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus, mitochondrion. Shuttles between nucleus and cytoplasm depending on environmental signals; sequestered into cytoplasm via 14-3-3 protein interaction; localizes to mitochondria under oxidative stress. Isoform IB: nucleus membrane, lipid-anchor; myristoylated c-ABL protein reported to be nuclear. |
Background
This gene encodes a proto-oncogene that produces a tyrosine kinase involved in cell division, adhesion, differentiation, and stress response. Its activity is negatively regulated by the SH3 domain; deletion of this region converts it into an oncogene. The protein binds DNA and its activity is modulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle. The gene is known to fuse with various translocation partners in leukemias, notably the t(9;22) translocation forming the BCR-ABL fusion gene. Alternative splicing results in two transcript variants with distinct first exons spliced to common downstream exons.
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