Thermo Fisher Scientific TCR beta Monoclonal Antibody (H57-597), APC-eFluor 780, eBioscience
마우스 TCR 베타 체인을 인식하는 H57-597 단클론 항체로, APC-eFluor 780 형광체가 결합된 제품입니다. 유세포 분석용으로 최적화되어 있으며, 633 nm 레이저에 의해 여기되어 780 nm에서 방출됩니다. 4°C 암소 보관, 빛에 민감하며 동결 금지.
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TCR beta Monoclonal Antibody (H57-597), APC-eFluor 780, eBioscience
Thermo Fisher Scientific TCR beta Monoclonal Antibody (H57-597), APC-eFluor 780, eBioscience
Applications and Tested Dilution
- Flow Cytometry (Flow): 1 µg/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), APC-eFluor™ 780 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H57-597 |
| Conjugate | APC-eFluor™ 780 |
| Excitation / Emission Max | 756 / 785 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1272209 |
Available Formats
- Unconjugated
- Alexa Fluor 532, 700
- APC, Biotin
- Brilliant UV/Violet/Yellow series
- eFluor 450, 506
- FITC, PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 600, 645, 702, 780
- NovaFluor Blue, UV, Violet, Yellow series
- Functional Grade
- Request custom conjugation
Product Specific Information
The H57-597 monoclonal antibody reacts with the beta chain of mouse TCR. TCR beta is expressed by thymocytes in a developmentally regulated manner and a majority of peripheral T cells. Crosslinking of the TCR complex with H57-597 induces activation and proliferation of T cells or apoptosis depending on assay conditions.
This antibody serves as a phenotypic marker for TCR beta-expressing T cells.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Tested on mouse splenocytes at ≤1 µg/test (in 100 µL volume, 10⁵–10⁸ cells/test)
- Excitation / Emission: 633–647 nm / 780 nm (Red laser)
- Light Sensitivity: Protect from light (photo-induced oxidation)
- Fixation: Samples can be stored in IC Fixation Buffer (Product #00-8222) or 1-step Fix/Lyse Solution (Product #00-5333) for up to 3 days at 4°C in the dark
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
T cell receptors (TCR) enable discrimination between self and foreign peptides presented by MHC class II molecules, essential for adaptive immune response.
Abnormal TCR recognition is associated with autoimmune diseases and tumors. Superantigen engagement can cause toxic shock syndrome.
Autoantibodies to V beta segments have been isolated from RA and SLE patients and may modulate inflammatory responses.
Most human T cells express TCR alpha-beta with CD4 or CD8; gamma-delta T cells show limited diversity and distinct antigen recognition, contributing to immunoregulatory and antitumor activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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