ELK Biotechnology ErbB-3 (phospho Tyr1222) rabbit pAb
ErbB-3 (phospho Tyr1222) rabbit polyclonal antibody로, HER3 단백질의 인산화 Tyr1222 부위를 특이적으로 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며 인체, 생쥐, 랫트 반응성을 가집니다. 세포막 및 분비형 isoform 검출에 적합합니다.
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제품명
ErbB-3 (phospho Tyr1222) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER3 around the phosphorylation site of Tyr1222 (AA range: 1191–1240) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 148 kD |
| GeneID (Human) | 2065 |
| Human Swiss-Prot No | P21860 |
| Cellular Localization | Isoform 1: Cell membrane, Single-pass type I membrane protein Isoform 2: Secreted |
| Species Reactivity | Human; Mouse; Rat |
배경 (Background)
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It can bind the ligand but does not convey the signal into the cell through phosphorylation. However, it forms heterodimers with other EGF receptor family members with kinase activity, leading to activation of pathways for cell proliferation or differentiation. Amplification or overexpression of this gene has been reported in various cancers, including prostate, bladder, and breast tumors. Alternate splice variants encode different isoforms, one of which is secreted and modulates cell signaling.
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