ELK Biotechnology AR-β2 (phospho Ser346) rabbit pAb
AR-β2 (phospho Ser346) rabbit pAb는 인간, 랫드, 마우스에서 사용 가능한 다클론 항체로, WB, IHC, IF, ELISA에 적합합니다. 인산화된 Ser346 부위를 인식하며, 세포막 및 골지체에서 발현되는 β2-아드레날린 수용체 연구에 유용합니다.
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제품명
AR-β2 (phospho Ser346) rabbit pAb
제품 개요
이 항체는 인간 Adrenergic Receptor β2의 Ser346 인산화 부위를 인식하는 다클론 항체로, WB, IHC, IF, ELISA 등 다양한 응용에 사용 가능합니다.
상세 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ADRB2; ADRB2R; B2AR; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Adrenergic Receptor β2 around the phosphorylation site of Ser346 (AA range: 321–370) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kDa |
| Gene ID (Human) | 154 |
| Human Swiss-Prot No. | P07550 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Early endosome; Golgi apparatus. Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to degradation in lysosomes (PubMed:20559325) and also detected within the Golgi apparatus (PubMed:27481942). |
Background
This gene encodes the beta-2-adrenergic receptor, a member of the G protein-coupled receptor (GPCR) superfamily. The receptor forms a complex with the class C L-type calcium channel Ca(V)1.2, G protein, adenylyl cyclase, cAMP-dependent kinase, and phosphatase PP2A. This assembly ensures specific and rapid signaling by the GPCR. The gene is intronless, and its polymorphisms or mutations are associated with nocturnal asthma, obesity, and type 2 diabetes.
(RefSeq, Jul 2008)
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