ELK Biotechnology ErbB-3 (phospho Tyr1197) rabbit pAb
ErbB-3 (phospho Tyr1197) rabbit polyclonal antibody로, HER3 인산화 부위를 인식합니다. WB 및 ELISA에 적합하며, 인간, 마우스, 랫트에서 반응합니다. 세포막 단백질 분석 및 신호전달 연구에 유용합니다.
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제품명
ErbB-3 (phospho Tyr1197) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER3 around the phosphorylation site of Tyr1197 (AA range: 1163–1212) |
| Host | Rabbit |
| Storage | -20°C for 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160–170 kDa |
| Gene ID (Human) | 2065 |
| Human Swiss-Prot No. | P21860 |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but lacks an active kinase domain. It can bind the ligand but cannot convey the signal through phosphorylation. However, it forms heterodimers with other EGFR family members possessing kinase activity, leading to activation of pathways responsible for cell proliferation and differentiation. Amplification or overexpression of this gene has been reported in various cancers, including prostate, bladder, and breast tumors. Alternative splicing generates isoforms, one of which is secreted and modulates the activity of the membrane-bound form.
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