ELK Biotechnology Neu (phospho Thr686) rabbit pAb
HER2 인산화 부위(Thr686)를 인식하는 rabbit polyclonal antibody로, IF 및 ELISA에 적합. 인간, 마우스, 랫트 반응성. 세포막 및 핵 내 HER2 단백 검출에 유용하며, 암 연구 및 신호전달 경로 분석에 활용 가능.
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제품명
Neu (phospho Thr686) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
본 항체는 인간 HER2 단백질의 Thr686 인산화 부위를 기반으로 제작된 rabbit polyclonal antibody입니다. HER2는 EGF receptor family에 속하는 수용체 티로신 키나아제로, 다양한 암종에서 과발현되는 것으로 알려져 있습니다. 본 항체는 인산화된 HER2 검출에 적합하며, 세포막 및 핵 내 단백질 위치 연구에 활용할 수 있습니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | Neu (phospho Thr686) rabbit pAb |
| Alternative Names | ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340 |
| Applications | IF; ELISA |
| Recommended Dilutions | Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER2 around the phosphorylation site of Thr686 (AA range: 661–710) |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kD |
| Gene ID (Human) | 2064 |
| Human Swiss-Prot No. | P04626 |
| Species Reactivity | Human; Mouse; Rat |
| Storage | -20°C, 1 year |
| Cellular Localization | Isoform 1: Cell membrane (single-pass type I membrane protein), early endosome, cytoplasm (perinuclear region), nucleus. Translocation to the nucleus requires endocytosis and importin beta-1/KPNB1 mediation. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles. Isoform 2: Cytoplasm, nucleus. Isoform 3: Cytoplasm, nucleus. |
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein lacks a ligand-binding domain of its own but forms heterodimers with other ligand-bound EGF receptor family members, enhancing downstream signaling pathways such as MAPK and PI3K. Amplification or overexpression of this gene is associated with various cancers, including breast and ovarian tumors. Alternative splicing results in several transcript variants.
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