ELK Biotechnology eIF4G (phospho Ser1148) rabbit pAb
eIF4G (phospho Ser1148) rabbit pAb는 인산화된 eIF4G 단백질을 검출하기 위한 폴리클로날 항체로, IHC, IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포질 내 스트레스 과립에서 발현되는 단백질 연구에 유용합니다.
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eIF4G (phospho Ser1148) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | eIF4G (phospho Ser1148) rabbit pAb |
| Alternative Names | EIF4G1; EIF4F; EIF4G; EIF4GI; Eukaryotic translation initiation factor 4 gamma 1; eIF-4-gamma 1; eIF-4G 1; eIF-4G1; p220 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | WB: 1:500–2000; IHC: 1/100–1/300; ELISA: 1/40000 (other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human eIF4G around the phosphorylation site of Ser1108 (AA range: 1074–1123) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 1981 |
| Human Swiss-Prot No. | Q04637 |
| Cellular Localization | Cytoplasm, Stress granule |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5′-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. (provided by RefSeq, Aug 2010)
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