ELK Biotechnology 4E-BP1 rabbit pAb
Human 4E-BP1 단백질을 인식하는 rabbit polyclonal antibody로, IHC, IF, ELISA에 사용 가능. eIF4E 결합 단백질 연구 및 단백질 번역 조절 메커니즘 분석에 적합. 고순도 IgG 형식으로 제공되며 -20°C에서 1년 보관 가능.
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ELK Biotechnology 4E-BP1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | 4E-BP1 rabbit pAb |
| Alternative Names | EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human 4E-BP1. AA range: 2–51 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 1978 |
| Human Swiss-Prot No | Q13541 |
| Cellular Localization | Nucleoplasm, cytoplasm, cytosol, protein complex |
| Species Reactivity | Human; Mouse; Rat |
Background
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) encodes a member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
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