ELK Biotechnology EphA2/5 (phospho Tyr594) rabbit pAb
EphA2/5 (phospho Tyr594) rabbit polyclonal antibody로, 인간 및 마우스 시료에 반응합니다. Western blot과 ELISA에 사용 가능하며, 세포막 단백질의 인산화 상태 분석에 적합합니다. 고순도 IgG, 1 mg/ml 농도로 제공되어 신뢰성 높은 결과를 제공합니다.
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제품명
EphA2/5 (phospho Tyr594) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA5; BSK; EHK1; HEK7; TYRO4; Ephrin type-A receptor 5; Brain-specific kinase; EPH homology kinase 1; EHK-1; EPH-like kinase 7; EK7; hEK7 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human EphA2/5 (phospho Tyr594) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 110 kD |
| GeneID (Human) | 1969 / 2044 |
| Human Swiss-Prot No | P29317 / P54756 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Single-pass type I membrane protein.
Cell projection, ruffle membrane; Single-pass type I membrane protein.
Cell projection, lamellipodium membrane; Single-pass type I membrane protein.
Cell junction, focal adhesion.
Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311).
Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797).
배경 (Background)
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors are involved in mediating developmental events, especially in the nervous system. Receptors in this subfamily typically possess a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. Ephrin receptors are divided into two groups based on extracellular domain sequence similarity and ligand binding affinities (ephrin-A and ephrin-B).
Mutations in this gene are associated with genetically-related cataract disorders. [provided by RefSeq, May 2010]
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