ELK Biotechnology EGFR (phospho Tyr869) rabbit pAb
EGFR (phospho Tyr869) rabbit pAb은 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로, Western Blot, IF, ELISA에 적합합니다. Tyr869 인산화 부위 기반 면역원으로 제작되었으며, 세포막 및 핵막 등 다양한 세포 위치에서 EGFR 검출에 활용됩니다.
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제품명
EGFR (phospho Tyr869) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human EGFR around the phosphorylation site of Tyr869 (AA range: 836–885) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kD |
| GeneID (Human) | 1956 |
| Human Swiss-Prot No | P00533 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치
Cell membrane; Single-pass type I membrane protein
Endoplasmic reticulum membrane; Single-pass type I membrane protein
Golgi apparatus membrane; Single-pass type I membrane protein
Nucleus membrane; Single-pass type I membrane protein
Endosome; Endosome membrane; Nucleus
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.
Background
The protein encoded by this gene is a transmembrane glycoprotein that belongs to the protein kinase superfamily. It acts as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, and ligand binding induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. Mutations in this gene are associated with lung cancer. (RefSeq, Jun 2016)
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