ELK Biotechnology EGFR (phospho Tyr1172) rabbit pAb
EGFR의 Tyr1172 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며 세포막 및 세포소기관에서의 EGFR 발현 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
EGFR (phospho Tyr1172) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human EGFR around the phosphorylation site of Tyr1172 (AA range: 1139–1188) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kD |
| Gene ID (Human) | 1956 |
| Human Swiss-Prot No. | P00533 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cell membrane; Single-pass type I membrane protein.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Golgi apparatus membrane; Single-pass type I membrane protein.
Nucleus membrane; Single-pass type I membrane protein.
Endosome; Endosome membrane; Nucleus.
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.
배경 (Background)
The protein encoded by this gene is a transmembrane glycoprotein that belongs to the protein kinase superfamily. It acts as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, leading to receptor dimerization, tyrosine autophosphorylation, and cell proliferation. Mutations in this gene are associated with lung cancer.
[provided by RefSeq, Jun 2016]
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