ELK Biotechnology EGFR (phospho Ser1070) rabbit pAb
EGFR의 Ser1070 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포막 및 핵막 등 다양한 세포소기관에서 EGFR 검출에 적합. -20°C에서 1년 보관.
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제품명
EGFR (phospho Ser1070) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human EGFR around the phosphorylation site of Ser1070 (AA range: 1041-1090) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kD |
| GeneID (Human) | 1956 |
| Human Swiss-Prot No | P00533 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cell membrane; Single-pass type I membrane protein
Endoplasmic reticulum membrane; Single-pass type I membrane protein
Golgi apparatus membrane; Single-pass type I membrane protein
Nucleus membrane; Single-pass type I membrane protein
Endosome; Endosome membrane; Nucleus
In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029).
Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029).
Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055).
Isoform 2: Secreted.
배경 정보
The protein encoded by this gene is a transmembrane glycoprotein that belongs to the protein kinase superfamily. It acts as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds epidermal growth factor, inducing receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. Mutations in this gene are associated with lung cancer. (RefSeq, Jun 2016)
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