ELK Biotechnology Ephrin-B3 rabbit pAb
Ephrin-B3 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 EFNB3 유래 펩타이드로 면역화되어 제작됨. 뇌 발달 및 신경계 연구에 적합하며, 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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Ephrin-B3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Ephrin-B3 rabbit pAb |
| Alternative Names | EFNB3; EPLG8; LERK8; Ephrin-B3; EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; LERK-8 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EFNB3 (AA range: 221-270) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 36 kD |
| Gene ID (Human) | 1949 |
| Human Swiss-Prot No | Q15768 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
EFNB3, a member of the ephrin gene family, is important in brain development and maintenance. EFNB3 expression levels are particularly high in several forebrain subregions, suggesting a pivotal role in forebrain function.
The EPH and EPH-related receptors form the largest subfamily of receptor protein-tyrosine kinases, mediating developmental events, especially in the nervous system.
EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats.
Ephrin ligands and receptors were named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into two classes:
- Ephrin-A (EFNA): anchored to the membrane by a glycosylphosphatidylinositol linkage
- Ephrin-B (EFNB): transmembrane proteins
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