ELK Biotechnology CHOP (phospho Ser30) rabbit pAb
CHOP (phospho Ser30) rabbit pAb는 인간 및 생쥐 시료에 반응하는 인산화 Ser30 부위 특이 항체입니다. Western blot, IHC, IF, ELISA 등에 적합하며, ER 스트레스 관련 CHOP 단백질의 세포 내 위치 및 발현 연구에 유용합니다.
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제품명
CHOP (phospho Ser30) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product name | CHOP (phospho Ser30) rabbit pAb |
| Alternative Names | DDIT3; CHOP; CHOP10; GADD153; DNA damage-inducible transcript 3 protein; DDIT-3; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; Growth arrest and DNA damage-inducible protein GADD153 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CHOP around the phosphorylation site of Ser30 (AA range: 15–64) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 19 kD |
| GeneID (Human) | 1649 |
| Human Swiss-Prot No | P35638 |
| Cellular Localization | Cytoplasm, Nucleus. Present in the cytoplasm under non-stressed conditions; ER stress leads to nuclear accumulation. |
| Species Reactivity | Human; Mouse |
배경 정보
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity.
It is implicated in adipogenesis and erythropoiesis, activated by endoplasmic reticulum stress, and promotes apoptosis.
Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma.
Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
[provided by RefSeq, Aug 2010]
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