ELK Biotechnology Doublecortin rabbit pAb
Doublecortin 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 미세소관 결합 단백질 연구에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
Doublecortin rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Doublecortin (AA range: 346–395) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kDa |
| Gene ID (Human) | 1641 |
| Human Swiss-Prot No | O43602 |
| Cellular Localization | Cytoplasm; Cell projection; Neuron projection; Localizes at neurite tips |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein containing two doublecortin domains that bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach their final differentiation site. The encoded protein directs neuronal migration by regulating microtubule organization and stability. It also interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, which is essential for proper microtubule function in the developing cortex. Mutations in this gene cause abnormal neuronal migration, disrupting cortical layering and leading to epilepsy, mental retardation, subcortical band heterotopia (“double cortex” syndrome) in females, and lissencephaly (“smooth brain”).
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