ELK Biotechnology Doublecortin (phospho Ser339) rabbit pAb
Doublecortin (phospho Ser339) rabbit pAb는 신경세포 이동 관련 단백질 DCX의 인산화 형태를 검출하는 항체입니다. IHC, IF, ELISA 등 다양한 응용 가능. 인간, 마우스, 랫트, 돼지 반응성. 세포 내 미세소관 결합 및 신경돌기 위치 특이적 검출에 적합.
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제품명
Doublecortin (phospho Ser339) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Doublecortin (DCX)는 신경세포 이동에 관여하는 미세소관 결합 단백질로, 본 항체는 Ser339 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Doublecortin around the phosphorylation site of Ser376 (AA range: 330–365) |
| Species Reactivity | Human; Mouse; Rat; Pig |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| GeneID (Human) | 1641 |
| Human Swiss-Prot No | O43602 |
| Cellular Localization | Cytoplasm; Cell projection; Neuron projection; Localizes at neurite tips |
Background
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein containing two doublecortin domains that bind microtubules. In the developing cortex, cortical neurons migrate over long distances to reach their final differentiation site. The encoded protein directs neuronal migration by regulating microtubule organization and stability. It interacts with LIS1, a regulatory gamma subunit of platelet activating factor acetylhydrolase, which is essential for proper microtubule function in cortical development. Mutations in this gene cause abnormal neuronal migration and cortical layering defects, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females, and lissencephaly ("smooth brain") in males.
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