ELK Biotechnology CYP2C8 rabbit pAb
CYP2C8 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간 CYP2C8 내부 영역에서 유래한 합성 펩타이드로 면역화되었으며, 55kDa 밴드 검출이 가능합니다. 약물 대사 관련 연구에 활용됩니다.
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제품명
CYP2C8 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CYP2C8; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human CYP2C8 |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kDa |
| GeneID (Human) | 1558 |
| Human Swiss-Prot No. | P10632 |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme metabolizes many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)
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