ELK Biotechnology Cathepsin D rabbit pAb
Cathepsin D rabbit pAb는 인간 및 생쥐 시료에서 Cathepsin D 단백질 검출에 적합한 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며, 높은 특이성과 안정성을 제공합니다. 단백질 분해 및 질병 연구에 활용됩니다.
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Cathepsin D rabbit pAb
제품 개요
Cathepsin D rabbit pAb는 인간 Cathepsin D 단백질의 내부 영역에서 유래한 합성 펩타이드로 면역화된 폴리클로날 항체입니다. 다양한 면역학적 분석(WB, IHC, IF, ELISA)에 사용 가능하며, 단백질 분해 및 관련 질환 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cathepsin D rabbit pAb |
| Alternative Names | CTSD; CPSD; Cathepsin D |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human Cathepsin D |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kD |
| Gene ID (Human) | 1509 |
| Human Swiss-Prot No | P07339 |
| Cellular Localization | Lysosome, Melanosome, Secreted extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380). |
| Storage | -20°C, stable for 1 year |
| Host Species | Rabbit |
Background
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene cause neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer’s disease. [provided by RefSeq, Nov 2015]
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