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ELK Biotechnology SIK1 rabbit pAb
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ELK Biotechnology SIK1 rabbit pAb

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인간 및 랫트 반응성을 가진 SIK1 rabbit polyclonal antibody로 WB 및 IHC에 적합. 세포질 및 핵 내 위치 검출에 활용 가능. 고순도 IgG 1 mg/ml 농도, -20°C에서 1년 보관.

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pk
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ELK Biotechnology ES4895-100UL SIK1 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES4895-50UL SIK1 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology SIK1 rabbit pAb

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SIK1 rabbit pAb

기본 정보

항목 내용
Alternative Names SIK1; SIK; SNF1LK; Serine/threonine-protein kinase SIK1; Salt-inducible kinase 1; SIK-1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK
Applications WB; IHC
Recommended Dilutions WB 1:500–2000; IHC-p 1:50–300
Immunogen Synthesized peptide derived from human SIK (AA range: 148–197)
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 85 kD
GeneID (Human) 150094
Human Swiss-Prot No P57059
Cellular Localization Cytoplasm, Nucleus. Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
Species Reactivity Human; Rat

Background

  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein
  • Cofactor: Magnesium
  • Enzyme regulation: Activated by phosphorylation on Thr-182 by STK11 in complex with STRADα and CAB39
  • Function: Plays a transient role during early myocardial and skeletal muscle differentiation; may regulate G2/M cell cycle; inhibits CREB activity by phosphorylating CRTC1–3
  • PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
  • Similarity: Belongs to protein kinase superfamily; CAMK Ser/Thr protein kinase family; AMPK subfamily; contains 1 protein kinase domain and 1 UBA domain
  • Subcellular location: Translocates to cytoplasm upon phosphorylation and binds YWHAZ
  • Subunit: Binds and is activated by YWHAZ when phosphorylated on Thr-182

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