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ELK Biotechnology SIK1 rabbit pAb
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인간 및 랫트 반응성을 가진 SIK1 rabbit polyclonal antibody로 WB 및 IHC에 적합. 세포질 및 핵 내 위치 검출에 활용 가능. 고순도 IgG 1 mg/ml 농도, -20°C에서 1년 보관.
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- pk
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ELK Biotechnology ES4895-100UL SIK1 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES4895-50UL SIK1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology SIK1 rabbit pAb
제품명
SIK1 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SIK1; SIK; SNF1LK; Serine/threonine-protein kinase SIK1; Salt-inducible kinase 1; SIK-1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human SIK (AA range: 148–197) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kD |
| GeneID (Human) | 150094 |
| Human Swiss-Prot No | P57059 |
| Cellular Localization | Cytoplasm, Nucleus. Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348). |
| Species Reactivity | Human; Rat |
Background
- Catalytic activity: ATP + a protein = ADP + a phosphoprotein
- Cofactor: Magnesium
- Enzyme regulation: Activated by phosphorylation on Thr-182 by STK11 in complex with STRADα and CAB39
- Function: Plays a transient role during early myocardial and skeletal muscle differentiation; may regulate G2/M cell cycle; inhibits CREB activity by phosphorylating CRTC1–3
- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR
- Similarity: Belongs to protein kinase superfamily; CAMK Ser/Thr protein kinase family; AMPK subfamily; contains 1 protein kinase domain and 1 UBA domain
- Subcellular location: Translocates to cytoplasm upon phosphorylation and binds YWHAZ
- Subunit: Binds and is activated by YWHAZ when phosphorylated on Thr-182
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