ELK Biotechnology AR α2A rabbit pAb
AR α2A rabbit polyclonal antibody로, 인간·마우스·랫트 시료에서 WB, IHC, IF, ELISA에 사용 가능. 인간 Adrenergic Receptor α2A 유래 펩타이드로 제작되어 높은 특이성과 재현성을 제공. 세포막 단백질 검출에 적합하며, -20°C에서 1년 보관 가능.
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제품명
AR α2A rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ADRA2A; ADRA2R; ADRAR; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2A (AA range: 331-380) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| Gene ID (Human) | 150 |
| Human Swiss-Prot No | P08913 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
Alpha-2-adrenergic receptors belong to the G protein-coupled receptor superfamily and include three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors play a critical role in regulating neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system. Studies in mice revealed that both alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity. This gene encodes the alpha2A subtype and contains no introns in either its coding or untranslated sequences. (provided by RefSeq, Jul 2008)
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