ELK Biotechnology c-Fms (phospho Tyr699) rabbit pAb
인간, 랫, 마우스에서 반응하는 c-Fms (phospho Tyr699) rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 세포막 단일 통과형 I 막단백질을 인식하며, 1 mg/ml 농도와 175 kD 밴드를 나타냅니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
c-Fms (phospho Tyr699) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CSF1R; FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD antigen CD115 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human c-Fms (phospho Tyr699) |
| Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kD |
| GeneID (Human) | 1436 |
| Human Swiss-Prot No | P07333 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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