Thermo Fisher Scientific KCNH1 Polyclonal Antibody
인간 KCNH1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 면역세포염색(ICC/IF)에 적합하며 항원 친화 크로마토그래피로 정제됨. 0.4 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C 보관 및 장기 -20°C 보관 권장.
- 카탈로그번호
- PA564954
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human KCNH1. Recombinant protein control fragment (Product #RP-91156) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662278 |
Product Specific Information
Immunogen sequence:
DSCDSGITKSD LRLDNVGEAR SPQDRSPILA EVKHSFYPIP EQTLQATVLE
VRHELKEDIK ALNAKMTNIE KQLSEILRIL TSRRSSQSPQ ELFEISRPQS PES- Highest antigen sequence identity to orthologs: mouse 91%, rat 92%
Target Information
Voltage-gated potassium (Kv) channels are a complex class of voltage-gated ion channels with diverse physiological roles, including regulation of neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
KCNH1 encodes a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation and is highly expressed in brain and myoblasts.
Overexpression of KCNH1 may confer a growth advantage to cancer cells and promote tumor proliferation. Alternative splicing results in two transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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