Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), FITC

Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (5H10), FITC

Applications

• Immunohistochemistry (Frozen) (IHC (F))
  Tested Dilution: –
  View 2 publications

• Flow Cytometry (Flow)
  Tested Dilution: Assay-dependent
  View 8 publications

• Miscellaneous PubMed (Misc)
  Tested Dilution: –
  View 2 publications

Product Specifications

Additional Conjugate Formats

• Alexa Fluor 488
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• Pacific Blue
• Pacific Orange
• PE
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family involved in T cell signal transduction, differentiation, and activation. It is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with TCR for MHC-I molecules. CD8α is essential for MHC-I binding and is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells. Interaction with MHC-I/peptide complexes recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs play a crucial role in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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