Thermo Fisher Scientific Melanophilin Monoclonal Antibody (OTI6E3)
Melanophilin 단백질을 인식하는 Mouse monoclonal 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 고순도의 Affinity Chromatography 정제 제품이며 PBS/BSA/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 295–600 of MLPH produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724675 |
Target Information
Slac2-a (synaptotagmin-like protein homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes.
Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus.
The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex. Mutations in the binding domains of these three protein components may cause albinism and/or severe immune disorders.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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