Thermo Fisher Scientific CD244 Monoclonal Antibody (eBioPP35 (PP35)), eBioscience
인간 CD244(2B4) 인식 단클론 항체로, NK 세포 및 일부 T 세포 표면 단백질 분석에 적합. Flow cytometry, Western blot, IP 등 다양한 응용 가능. 액상 형태로 제공되며, 고순도(>90%) 및 낮은 응집도(<10%) 보장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-Dependent | - |
| Flow Cytometry (Flow) | Assay-Dependent | - |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Neutralization (Neu) | - | 1 publication |
| Inhibition Assays (IA) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioPP35 (PP35) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_763464 |
Additional Formats
Product Specific Information
The eBioPP35 monoclonal antibody reacts with human CD244 (also known as 2B4, p38, NK-cell activation-inducing ligand, SLAMF4, and natural killer cell receptor 2B4).
CD244 is a 38 kDa protein expressed on NK cells, subsets of CD8⁺ T cells, γδ T cells, monocytes, basophils, mast cells, and eosinophils. Binding of CD244 to its ligand CD48 induces NK cell activation. Costaining with eBioC1.7 suggests recognition of distinct epitopes.
Applications Reported: Flow cytometry, immunoprecipitation, and Western blotting (WB).
Purity: >90% (SDS-PAGE).
Aggregation: <10% (HPLC).
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD244 (2B4, SLAMF4) is a cell surface receptor on NK cells and some T cells that mediates non-MHC restricted cytotoxicity. Interaction with SLAMF2 (CD48) modulates NK-cell activity. Reduced SLAMF4 expression has been observed in systemic lupus erythematosus, implicating CD244 in autoimmune pathology. Dysregulation of CD244 is also linked to rheumatoid arthritis and lymphoproliferative syndromes.
Alternative splicing results in multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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