Thermo Fisher Scientific Caspase-1 P10 Polyclonal Antibody
Caspase-1 단백질 검출용 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat, Chicken 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Caspase-1 (amino acids 320–404) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala, leading to the release of mature cytokine involved in inflammatory processes. CASP1 plays a key role in defense against pathogens, activates sterol regulatory element binding proteins (SREBPs), and promotes apoptosis. Upon inflammasome activation during DNA virus infection, CASP1 controls antiviral immunity through cleavage and inactivation of CGAS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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