Thermo Fisher Scientific SMAD4 Monoclonal Antibody (SMAD4, 2524)
SMAD4 단백질을 인식하는 Mouse monoclonal antibody로, ELISA에 최적화되어 있습니다. Human 시료에 반응하며, Protein A/G로 정제된 액상형 제품입니다. 보존제가 없으며, -20°C 이하에서 보관 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications
- ELISA (Direct ELISA)
- Tested Dilution: Assay-dependent
- For coating use: 1–5 µg/mL
- This antibody has only been tested in direct ELISA.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SMAD4, 2524 |
| Immunogen | Recombinant full-length human SMAD4 protein (aa 1–552) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C (preferred) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody tested in direct ELISA only.
- Recommended coating concentration: 1–5 µg/mL.
- For Research Use Only. Not for use in diagnostic procedures.
- Not for resale without express authorization.
Target Information
Smad4 is encoded by the SMAD4 gene located on chromosome 18 in humans. Also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic homolog 4.
Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) domains involved in DNA binding and protein interactions.
Activation of TGF-β or BMP receptors leads to phosphorylation of R-Smads (Smad1, 2, 3, 5, 8), which then form complexes with Smad4 (co-Smad) and translocate to the nucleus to regulate gene expression.
Smad4 functions as a tumor suppressor by regulating genes such as Cyclin D1 (downregulation) and collagen (upregulation), influencing cell proliferation and differentiation.
Dephosphorylation controls nuclear export and nucleocytoplasmic dynamics of Smads.
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