Thermo Fisher Scientific SHOC2 Polyclonal Antibody
SHOC2 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제, PBS/glycerol buffer에 보관. RAS-MAPK 신호전달 연구에 적합.
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- PA5106340
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SHOC2 (Accession Q9UQ13), corresponding to amino acid residues S532–V582. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854016 |
Product Specific Information
Antibody detects endogenous levels of total Sur-8.
Target Information
SHOC2 protein participates in protein binding and transferase activity within the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction.
It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR) with a lysine-rich sequence at the amino terminus and localized in the cytoplasm.
SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, mediated by EGL-15, LET-23, and LET-60. Together with protein phosphatase 1c (PP1c), SHOC2 forms an M-Ras effector complex essential for MAPK pathway activation.
In tumor cells with Ras mutations, inhibition of SHOC2 suppresses MAPK but not PI3K activity, making the SHOC2-PP1c holoenzyme a potential therapeutic target.
Aberrant N-myristoylation of SHOC2 has been linked to Noonan-like syndrome with loose anagen hair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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