Thermo Fisher Scientific MCM4 Polyclonal Antibody
Goat에서 유래한 MCM4 폴리클로날 항체로, WB 및 IHC에 최적화된 연구용 시약입니다. 인간 MCM4 단백질의 325-375 잔기 영역을 면역원으로 사용하며, 액상 형태로 1 mg/mL 농도입니다. 4°C 보관, 웻 아이스 배송.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 325 and 375 of human Minichromosome Maintenance 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre_RC) and may be involved in replication fork formation and recruitment of other DNA replication-related proteins.
MCM2, 6, and 7 together with this protein possess DNA helicase activity and may act as a DNA unwinding enzyme. Phosphorylation by CDC2 kinase reduces helicase activity and chromatin binding.
This gene is located on chromosome 8, adjacent to PRKDC/DNA-PK involved in DNA double-strand break repair. Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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