Thermo Fisher Scientific Fbx32 Polyclonal Antibody
Fbx32 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, Flow cytometry, ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도의 액상 형태로 제공. 근육 위축 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Fbx32 (amino acids 31–130) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Fbx32 gene encodes a member of the F-box protein family, characterized by a ~40 amino acid F-box motif. These proteins are subunits of the SCF ubiquitin ligase complex, functioning in phosphorylation-dependent ubiquitination. F-box proteins are classified into three groups:
- Fbws with WD-40 domains
- Fbls with leucine-rich repeats
- Fbxs with other interaction modules or no recognizable motifs
Fbx32 belongs to the Fbxs class and contains an F-box domain. It is highly expressed during muscle atrophy, and mice deficient in this gene show resistance to atrophy. Therefore, Fbx32 is a potential drug target for muscle atrophy treatment. Alternative splicing results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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