Thermo Fisher Scientific DLL4 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1284)
DLL4 단백질을 인식하는 알파카 유래 재조합 단일클론 항체로, ELISA 등 연구용 분석에 적합합니다. CHO 세포에서 발현되며, 금속 킬레이트 크로마토그래피로 정제되었습니다. 인간 DLL4에 특이적으로 반응하며, 비결합 상태의 액상 형태로 제공됩니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1284 |
| Immunogen | Recombinant Human DLL4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Delta-like ligand 4 (DLL4), also known as Delta-4, is a homologue of the Drosophila delta protein and functions as a transmembrane-bound ligand to the Notch receptor Notch1.
DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF) as a negative feedback regulator to control angiogenic sprouting and promote the formation of a differentiated vascular network.
DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 leads to increased vascular proliferation but defective maturation, resulting in decreased tumor growth without apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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