Thermo Fisher Scientific KLC1 Recombinant Rabbit Monoclonal Antibody (ARC2409)
Thermo Fisher의 KLC1 재조합 토끼 단클론 항체(ARC2409)는 인간, 마우스, 랫트 시료에서 Kinesin light chain 1 단백질을 검출하는 데 사용됩니다. WB 및 ELISA에 최적화된 고순도 항체로, HEK293 세포에서 발현된 IgG 형식이며 -20°C에서 안정적으로 보관됩니다.
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Thermo Fisher Scientific KLC1 Recombinant Rabbit Monoclonal Antibody (ARC2409)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2409 |
| Immunogen | Synthetic peptide corresponding to amino acids 450–550 of human Kinesin light chain 1 (KLC1) (UniProt ID: Q07866) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897802 |
Product Specific Information
- Positive Samples: 293T, MCF7, U-87MG, Mouse brain, Rat brain
- Immunogen sequence:
GGWYKACKVD SPTVTTTLKN LGALYRRQGK FEAAETLEEA AMRSRKQGLD NVHKQRVAEV LNDPENMEKR RSRESLNVDV VKYESGPDGG EEVSMSVEWN G
Target Information
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, transporting various cargos along microtubules toward their plus ends. The heavy chains provide motor activity, while the light chains bind to cargos.
KLC1 encodes a member of the kinesin light chain family that associates with kinesin heavy chain through an N-terminal domain. Six tetratricopeptide repeat (TPR) motifs are involved in binding cargos such as vesicles, mitochondria, and the Golgi complex. Kinesin light chains act as adapter molecules rather than motors.
Although previously named “kinesin 2,” this gene is not part of the kinesin-2 heavy chain subfamily. Extensive alternative splicing produces isoforms with different C-termini that may bind distinct cargos; however, the full-length nature of some variants remains undetermined.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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