Thermo Fisher Scientific DDR2 Monoclonal Antibody (3B11E4)
Human DDR2 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합함. DDR2 관련 신호전달 및 세포 분화 연구에 활용 가능. 비결합형 액상 형태로 제공되며, 장기 보관 시 -20°C에서 안정적.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | 1 publication |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B11E4 |
| Immunogen | Purified recombinant fragment of human DDR2 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10986169 |
Product Specific Information
MA5-15356 targets DDR2 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human DDR2 expressed in E. coli.
Target Information
DDR2 is a receptor tyrosine kinase (RTK) that includes a distinct extracellular region with a factor VIII-like domain. DDR1 and DDR2 are potently inhibited by Gleevec. DDR2 is required for normal bone development and regulates osteoblast differentiation and chondrocyte maturation via MAP kinase signaling leading to RUNX2 activation. It also regulates extracellular matrix remodeling by upregulating collagenases MMP1, MMP2, and MMP13, facilitating cell migration and tumor invasion. DDR2 promotes fibroblast migration and proliferation, contributing to cutaneous wound healing.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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