Thermo Fisher Scientific E-cadherin Monoclonal Antibody (67A4), FITC

Applications

• Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
• View 2 publications

Product Specifications

Additional Formats

• Unconjugated (MA1-10192)
• APC (MA1-10193)
• PE (A15784)
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD324 / E-cadherin, an approximately 100 kDa epithelial cell adhesion molecule. Detection of this molecule is important for determining the invasive potential of epithelial neoplasms.

Target Information

E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
Mutations in the CDH1 gene, which encodes E-cadherin, are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss or reduction of E-cadherin expression correlates with increased tumor invasion and metastasis.
E-cadherin plays a central role in maintaining epithelial tissue architecture and integrity, and its ectodomain mediates bacterial adhesion to mammalian cells.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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