Thermo Fisher Scientific PAR4 Polyclonal Antibody
PAR4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. 고순도 액상 형태로 제공되며, -20°C에서 보관. 암세포의 세포사멸 연구 및 신호전달 경로 분석에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PAR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms.
The intracellular mechanism involves inhibition of pro-survival pathways and activation of Fas-mediated apoptosis, while the extracellular mechanism involves binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, leading to activation of the extrinsic apoptotic pathway.
This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated in different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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