Thermo Fisher Scientific Human THEM4 Synthetic Peptide
인간 THEM4 단백질의 중심부 18개 아미노산 서열로 구성된 합성 펩타이드. PA5-20773 항체의 블로킹 펩타이드로 사용 가능. 액상 형태로 200 µg/mL 농도, PBS(pH 7.2)와 0.1% BSA 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- PEP0887
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human THEM4.
PEP-0887 can be used as a blocking peptide with polyclonal antibody PA5-20773.
Target Information
THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells.
Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer.
Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase.
Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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