
Thermo Fisher Scientific PCBP1 Monoclonal Antibody (OTI3B9)
Human PCBP1 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P) 분석에 적합. 고순도 Affinity Chromatography 정제, 1 mg/mL 농도. 연구용으로만 사용 가능하며 안정적 저장 조건 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–225 of PCBP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724951 |
Target Information
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. Along with PCBP-2 and hnRNPK, it corresponds to the major cellular polydomains involved in RNA binding. This encoded protein, together with PCBP-2, also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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